What is histamine intolerance (HIT)?

Histamine intolerance (HIT) is caused by the inability of the body to breakdown histamine efficiently.

What causes histamine intolerance?
Insufficient levels, or reduced activity of the enzymes diamine oxidase (DAO) or histamine N-methyltransferase (HNMT), enables both endogenous and exogenous sources of histamine to increase histamine levels within the body.

Symptoms of histamine intolerance?

• Runny nose

• Sneezing

• Asthma

• Diarrhoea

• Abdominal cramps

• Dysmenorrhea

• Fatigue

• Flushing (face and chest)

• Headaches

• Hypotension (low blood pressure)

• Itchiness


Why test for histamine intolerance?

Until recently, the conventional method for diagnosing HIT was to adopt a low-histamine diet for several weeks and then observe if symptoms improved. However, following a low histamine diet can be very restrictive, especially as it requires individuals to avoid healthy foods. Being able to test for histamine intolerance can provide assurance to clients that they are restricting the diet for good reason, whilst enabling them to look at which cofactors may be beneficial in their programme.

How does the test work?

Utilising proven ELISA-based technology, the DAO Screen test offers a convenient and reliable method to detect circulatory levels of DAO in the bloodstream.

What are the sample requirements and test turn around?

The test is easy to perform and only requires a finger prick sample collected on as a Dried Blood Spot (DBS) sample. Everything required to perform the test is included in the kit sent and once your sample has been taken all you need to do is return it to the CNS laboratory in the prepaid envelope. To ensure your sample is not rejected please follow the instructions carefully and don’t press/scrape blood onto the collection card. At least 2 circles should be FULLY SATURATED and left to dry for 3+ hours (overnight is fine). To ensure a quick turnaround of results please send samples to the lab as soon as they have dried. A test report that details the DAO concentration detected in the blood sample will be available within 15 working days.


Sources  Cambridge Nutritional Science